Life Sciences Blog

Focused on the Business of Healthcare and Healthcare Innovation

Executive Summary (Chapter 1) In this article, we illustrate how personalized medicine will change the pharmaceutical industry.  When one contemplates the complexity of the future environment, it becomes quite clear that existing discovery, development, regulatory, commercialization, and reimbursement frameworks are nowhere near prepared for the changes coming with personalized medicine. It is imperative that pharmaceutical …

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Drug Discovery (Chapter 2) Over the years, research and discovery teams have deployed numerous techniques to identify “trial-worthy” compounds.  Some discovery was pure serendipity (e.g. penicillin) while others were the result of decades of research in molecular pathways (e.g. lovastatin).   Some drug discovery techniques have included: Combing the rain forests and oceans to find bacteria, …

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Drug Development (Chapter 3) In drug development, a series of preclinical safety, toxicity and efficacy studies are performed in vitro and in animals prior to administering these drugs to humans.  Clinical trials are designed to first addressing safety, then dosing, then efficacy, and finally larger Phase III trials to look at efficacy and other endpoints …

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